An agent in the FBI's Elite Serial Crime Unit develops profiling techniques as he pursues notorious serial killers and rapists.
Tom Kirkman, a low-level cabinet member is suddenly appointed President of the United States after a catastrophic attack during the State of the Union kills everyone above him in the Presidential line of succession.
Raymond "Red" Reddington, one of the FBI's most wanted fugitives, surrenders in person at FBI Headquarters in Washington, D.C. He claims that he and the FBI have the same interests: bringing down dangerous criminals and terrorists. In the last two decades, he's made a list of criminals and terrorists that matter the most but the FBI cannot find because it does not know they exist. Reddington calls this "The Blacklist". Reddington will co-operate, but insists that he will speak only to Elizabeth Keen, a rookie FBI profiler.