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One gunshot, one death, one moment out of time that irrevocably links eight minds in disparate parts of the world, putting them in each other's lives, each other's secrets, and in terrible danger. Ordinary people suddenly reborn as "Sensates."

Raymond "Red" Reddington, one of the FBI's most wanted fugitives, surrenders in person at FBI Headquarters in Washington, D.C. He claims that he and the FBI have the same interests: bringing down dangerous criminals and terrorists. In the last two decades, he's made a list of criminals and terrorists that matter the most but the FBI cannot find because it does not know they exist. Reddington calls this "The Blacklist". Reddington will co-operate, but insists that he will speak only to Elizabeth Keen, a rookie FBI profiler.

A modern update finds the famous sleuth and his doctor partner solving crime in 21st century London.

After 250 years on ice, a prisoner returns to life in a new body with one chance to win his freedom: by solving a mind-bending murder.